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FRACFRAC (2025) FRAC Code List© 2025: Fungal control agents sorted by cross-resistance pattern and mode of action. CropLife International, May 2025, 18pp. (Industry-canonical mode-of-action classification published by the Fungicide Resistance Action Committee — used here for the group-by-group resistance-risk classifications and named-active enumerations.)

Fungicide Resistance Management — UK Doctrine

What it is

The UK-applicable doctrine for fungicide resistance management — how to rotate chemistry to preserve the actives that remain after the withdrawals documented in withdrawn-actives-uk-reference. The canonical mechanism is mode-of-action rotation (FRAC-group cycling), anchored to Penn State Extension's published resistance discipline for Clarireedia jacksonii and applied to the UK climate-pressure and chemistry-loss context surfaced in BIGGA's 2024 and 2025 coverage.

This entry is the stewardship-doctrine companion to the withdrawn-actives reference: that entry documents what's been lost; this entry documents how to keep what remains effective. The framing matters because UK supes face a compounding pressure — withdrawn actives + climate-driven disease expansion (Kirby on dollar-spot; Perfect Storm 2025 on Microdochium) + ongoing resistance selection pressure on the remaining chemistry — and the doctrine response is cultural management first, chemistry-rotated second, repeat-class applications avoided.

The FRAC framework — group-by-group breakdown

The Fungicide Resistance Action Committee (FRAC), a CropLife International committee, publishes the canonical industry classification of fungicides by mode of action and cross-resistance pattern. The FRAC Code List 2025 is the load-bearing reference for what follows [frac:code-list-2025]; the UK-applicable subset of penetrant + contact groups that show up in greens-area programmes is enumerated below, each with FRAC's published resistance-risk classification.

Penetrant classes — the rotation-discipline core

The three penetrant classes dominate UK greens-area fungicide programmes today; all three are FRAC-classified Medium-to-High risk and require active rotation discipline.

FRAC 3 — DMI / demethylation inhibitors (Medium Risk)

Group name: DMI-fungicides — SBI: Class I. Sterol biosynthesis inhibitors targeting C14-demethylase in sterol production (erg11/cyp51) [frac:code-list-2025].

Turf-relevant active ingredients (FRAC 2025 + Penn State enumeration [psu-turf:landschoot-2023]): propiconazole, tebuconazole, prothioconazole (a triazolinthione), flutriafol, difenoconazole, myclobutanil, mefentrifluconazole, metconazole.

Resistance status: FRAC classifies Group 3 as Medium Risk. The SBI Class I families (triazoles + imidazoles) share cross-resistance within the group but no cross-resistance to other SBI classes [frac:code-list-2025]. Penn State documents penetrant resistance in C. jacksonii generally [psu-turf:landschoot-2023]; FRAC-published SBI guidelines flag the need for resistance management on this group.

Rotation rule (UK greens-area context): rotate with FRAC 7 or 11, or pair with M5 / contact during high-pressure windows. A second DMI application back-to-back from a different chemistry sub-family (e.g. propiconazole → tebuconazole) is not rotation — both select for the same target-site resistance.

FRAC 7 — SDHI / succinate dehydrogenase inhibitors (Medium-to-High Risk)

Group name: SDHI — Carboxamides. Inhibitors of mitochondrial complex II (succinate dehydrogenase, sdh) [frac:code-list-2025].

Turf-relevant active ingredients (FRAC 2025): boscalid (a pyridine- carboxamide), fluxapyroxad, isofetamid (a phenyl-oxo-ethyl thiophene amide), benzovindiflupyr, penthiopyrad, sedaxane, fluopyram (a pyridinyl- ethyl-benzamide), pydiflumetofen.

Resistance status: FRAC classifies Group 7 as Medium to High Risk. Resistance is known in several fungal species, with target-site mutations in the sdh gene at codons 257/267/272 (H/Y or H/L substitutions) or P225L, species-dependent [frac:code-list-2025]. FRAC publishes dedicated SDHI Guidelines for Resistance Management.

Rotation rule: rotate with FRAC 3 or 11; never two SDHI applications back-to-back regardless of sub-family. Sub-family swapping (boscalid → fluxapyroxad) does not break cross-resistance because the mutations selected confer cross-class resistance.

FRAC 11 — QoI / strobilurins (High Risk)

Group name: QoI-fungicides — Quinone outside Inhibitors. Target the cytochrome bc1 complex at the Qo site (cyt b gene) [frac:code-list-2025].

Turf-relevant active ingredients (FRAC 2025 + Penn State [psu-turf:landschoot-2023]): azoxystrobin (methoxy-acrylate), pyraclostrobin (methoxy-carbamate), trifloxystrobin (oximino-acetate), kresoxim-methyl, mandestrobin (methoxy-acetamide), fluoxastrobin (dihydro-dioxazine), picoxystrobin.

Resistance status: FRAC classifies Group 11 as High Risk — the sharpest resistance-risk classification across the penetrant groups in common UK use. The G143A target-site mutation in the cyt b gene confers full cross-resistance across all Code 11 members for G143A mutants [frac:code-list-2025]. F129L is the secondary mutation. FRAC publishes dedicated QoI Guidelines for Resistance Management.

Rotation rule: rotate with FRAC 3 or 7; QoI back-to-back is the highest-risk repeat-class pattern in the penetrant inventory. The G143A "full cross-resistance" finding means rotation must cross to a different FRAC code, not a different QoI sub-family.

The withdrawn-class baseline

FRAC 1 — MBC / benzimidazoles (High Risk, withdrawn UK)

Group name: MBC-fungicides — Methyl Benzimidazole Carbamates. Inhibit tubulin polymerisation (β-tubulin gene) [frac:code-list-2025].

Active ingredients (historical UK relevance): carbendazim, benomyl, thiabendazole.

Resistance status: FRAC classifies Group 1 as High Risk. Resistance is common across many fungal species, with multiple target- site mutations in β-tubulin (E198A/G/K, F200Y), positive cross- resistance between group members, and negative cross-resistance to N-phenyl carbamates [frac:code-list-2025].

UK status: carbendazim and benomyl are withdrawn from UK authorisation. The MBC class is a historical reference for UK greens programmes — relevant only insofar as the resistance pressure FRAC classifies as High already played out on UK turf before withdrawal, illustrating the resistance-selection failure mode the doctrine in this entry is designed to prevent recurrence of. See withdrawn-actives-uk-reference.

The multi-site / contact class

FRAC M 05 — chloronitriles / phthalonitriles (Low Risk, withdrawn EU)

Group name: Chloronitriles (phthalonitriles) — multi-site contact activity, unspecified mechanism [frac:code-list-2025].

Active ingredient: chlorothalonil.

Resistance status: FRAC's M-class header states multi-site contact activity is "generally considered as a low risk group without any signs of resistance developing to the fungicides" [frac:code-list-2025]. This is the structural reason contact / multi-site materials are the doctrinally-preferred rotation partner for the penetrant classes — they break the per-event selection-pressure chain without contributing back to penetrant-class resistance pools.

UK status: chlorothalonil was withdrawn across the EU from 20 May 2020 — the binding event for UK greens programmes. The M5 class is operationally lost to UK supes; the multi-site rotation partner role that chlorothalonil filled historically is no longer available via this specific chemistry. See withdrawn-actives-uk-reference for the wider chemistry-loss context.

What "rotation" actually means

The discipline is rotate across FRAC codes, not just rotate active ingredients. Two FRAC 11 applications back-to-back from different brand products are not rotation — both apply the same mode of action and select for the same resistance mechanism (G143A on cyt b for QoI; sdh mutations for SDHI; erg11 / cyp51 for DMI). Eagle AI surfaces that recommend or log fungicide applications should track at the FRAC-code level, not at the trade-name or active-ingredient level.

Contact fungicides are a structurally separate class. Penn State explicitly includes them in the rotation strategy [psu-turf:landschoot-2023]: "Both contact and penetrant fungicides are effective in controlling this disease." A programme that uses contact-only or alternates contact-with-penetrant materially reduces the resistance-selection pressure on the penetrant classes — but the UK loss of chlorothalonil (M5) has narrowed this lever significantly relative to pre-2020 programmes.

The C. jacksonii resistance evidence

Penn State Extension is explicit about documented resistance [psu-turf:landschoot-2023]: "resistance to penetrant fungicides has occurred with C. jacksonii." That is the published evidence that the rotation discipline is not theoretical — UK supes running dollar-spot-active programmes today are working against a pathogen population with confirmed penetrant-fungicide resistance somewhere in its global distribution.

The operational consequence is asymmetric: a UK supe whose local C. jacksonii population has not yet developed resistance gains nothing operationally from non-rotated applications (the penetrant still works) but takes on a non-zero probability of selecting for resistance with each repeat application. The expected-value calculus is rotate-by-default; depart from rotation only with deliberate justification.

UK climate-pressure compounding

The resistance-management discipline is more important in UK greenkeeping in 2025 than it was a decade ago, not less. Two compounding factors:

(1) Climate-driven disease expansion. Glenn Kirby (STRI Research Director, via BIGGA) frames dollar-spot specifically as climate-shift- favoured [bigga:2024-dollar-spot]: "the climate is moving in a direction that massively favours dollar spot," driven by high UK humidity + a warmer climate + milder winters that prevent the cold-break spore-population reductions of previous decades. More disease pressure = more spray events = more selection pressure per season = faster resistance emergence if rotation discipline lapses. See dollar-spot-management and microdochium-snow-mould for the disease-side framing.

(2) Diminished chemistry inventory. Iprodione (the Microdochium- control workhorse for UK greens) was withdrawn in 2018; carbendazim, chlorpyrifos, and imidacloprid were withdrawn earlier (see withdrawn-actives-uk-reference). With fewer modes of action available in the toolbox, each remaining mode of action carries higher operational weight — losing a class to resistance after the 2018 withdrawals is more consequential than it would have been when the inventory was larger.

BIGGA's 2025 Perfect Storm coverage captures the on-the-ground consequence [bigga:2025-perfect-storm]: "Products are less effective and we must remember, they don't kill Microdochium; they slow its growth." The framing is operationally important — UK supes are already running with reduced fungicide efficacy on the worst- pressure events; resistance-driven further efficacy loss is the critical-failure-mode case the rotation discipline is designed to prevent.

The integrated approach — cultural first, chemistry-rotated second

Penn State's standing recommendation pairs the rotation discipline with a cultural-management floor [psu-turf:landschoot-2023]: "Perhaps the best way to lessen the chance of resistance developing is to employ a broad-based cultural management program that reduces the number of fungicide applications over the course of the growing season."

This is the fewer-applications-per-season reframing of resistance management — every spray event is a selection-pressure event, so not spraying is the most reliable resistance-management lever. The cultural levers already documented across the corpus (dollar-spot-management §"Cultural management (IPM)", mowing-heights-cool-season §"Cultural-first context", withdrawn-actives-uk-reference) are the operational substrate of this discipline. The chemistry rotation is what you do for the events you must spray; the cultural program is what reduces the number of those events.

Operational read for Eagle AI

The recommendations layer should treat fungicide-application recommendations as a constrained optimisation, not a free choice:

  • Track FRAC-group history per zone — the "what mode of action did this surface last receive?" data point is the binding constraint on the next application. Eagle AI's task-history surface should record FRAC group, not just brand name.
  • Default-recommend rotation — if the last application was DMI/3, the next-default should be SDHI/7 or QoI/11 (or contact).
  • Surface the cultural alternatives first — if the recommendation layer is suggesting any fungicide, it should first surface what cultural-management adjustments would reduce the need (dew removal tighter, irrigation regime, mowing height raise, rolling-frequency increase, etc.). Spraying is the action-of-last-resort framing.
  • Flag repeat-class applications — if a supe configures or accepts two same-FRAC-group applications in a row, the surface should display the resistance-selection-pressure context, not block the action. Supe-override always wins; the surface's job is to make the decision informed.

When to deviate

The supe's configured spray programme always overrides this entry. Reasons to depart from strict-rotation discipline:

  • Diagnostic-confirmed pathogen with class-specific susceptibility — when lab diagnosis confirms a population that responds to one class far better than alternatives, leaning on that class is defensible despite rotation principle.
  • Pre-tournament window — championship prep operates on a different time-horizon; rotation can be deferred to the post-event recovery window.
  • Curative emergency — active outbreak where rotation discipline would mean a known-less-effective class right now. Treat first; rotate next.

In all three cases, the deviation is deliberate and bounded, not the default.

<!-- WRITER NOTE (library-curator-2, 2026-05-20, frac-expansion v2): Version 2 — added FRAC as the new whitelisted primary anchor (replacing Penn State as v1's primary), then deepened §"The FRAC framework" from a 3-group penetrant enumeration to a full 5-group breakdown (3 + 7 + 11 + 1 + M5) with FRAC-published resistance-risk classifications per group. Primary citation switch rationale: FRAC Code List 2025 (frac.info) is industry-canonical for mode-of-action classification — same tier as USGA/BIGGA/R&A/STRI/GCSAA/FEGGA/USDA. Penn State stays as secondary authority for the operational rotation discipline + the C. jacksonii resistance-evidence framing. `frac` tag added to whitelist in this PR's _config/approved-sources.yml + scripts/verify-entries.ts WHITELISTED_TAGS union update — Agent A ratified path-1 (new tag) over path-2 (workaround via BIGGA/R&A/MSU intermediate) per the Inv #8 supe-side audit-chain requirement. Companion entry created in this PR: frac-codes-reference-uk.md (quick-lookup card per FRAC code — doctrine here, lookup there). eagle-ai-ux types sync (src/lib/library/types.ts PrimarySourceTag) is a separate follow-up PR in that consumer repo; this PR cannot reach it. This entry now has heavier-than-typical cross-reference density — pulls from withdrawn-actives, dollar-spot-management, microdochium- snow-mould, mowing-heights-cool-season, climate-adaptation, and the new frac-codes-reference-uk. By design — fungicide resistance management IS the doctrine layer that ties those disease- and culture- focused entries together. --> <!-- WRITER NOTE (library-curator-2, 2026-05-21, smith-kerns-thresholds): Smith-Kerns dollar-spot prediction model (2018 logistic regression with 5-day rolling RH + temp + 20% action threshold + temperature- bounded inactivity rule) was previously deferred per `_index/gaps.md:dollar-spot-smith-kerns-model` — TDL access opened 2026-05-21 via tdl.wisc.edu/dollar-spot-model/ + addition of `wisc-turf` (University of Wisconsin-Madison TDL) to the USDA umbrella whitelist. Model content now lives in [`dollar-spot-management`](dollar-spot-management.md) §"Smith-Kerns prediction model" rather than a standalone entry — that placement keeps the model's operational thresholds inline with the disease-management decision tree, avoiding a thin standalone scaffold. Gap closed in this PR. -->

Related

  • withdrawn-actives-uk-reference — the chemistry-loss baseline that this entry's resistance discipline is designed to protect against further depletion
  • dollar-spot-management §"Fungicide- resistance discipline" — the operational application of the rotation doctrine on the most-prevalent UK climate-pressured disease; Penn State quote on penetrant-rotation appears in both entries
  • microdochium-snow-mould §"Management reality: slow, not stop" — the post-iprodione Microdochium framing where the "products less effective" pressure is sharpest
  • mowing-heights-cool-season §"Cultural-first context — fungicide loss as a height-of-cut driver" — the cultural-floor side of the integrated-management pair this entry is the chemistry-side of
  • climate-adaptation-uk-course-management — the doctrine entry on climate-driven adaptation across UK supes; Rogers's September→October Fusarium-treatment shift pairs with this entry's rotation cadence framing
  • frac-codes-reference-uk — companion quick-lookup reference: one-line summary per FRAC code (number, MoA group, named actives, FRAC risk, UK status). This entry is the doctrine; the reference card is the at-glance lookup
  • dollar-spot-management §"Smith-Kerns prediction model" — the canonical weather-based decision-support model for dollar-spot fungicide timing (5-day RH + temp logistic regression, 20% action threshold, <10°C / >35°C inactivity bounds); the supe's choice to spray flows directly into this entry's rotation discipline above